Abstract: The centers for disease control and prevention are assuming an increasingly important role in the field of public health in China. Furthermore, higher requirements have been put forward for national disease control centers in the new era under the new situation of China. As the security and technical support and an inevitable trend for disease prevention and control, a digital management system complying with the current quality and safety standards has been developed for the laboratory to effectively improve the capacity of laboratories in disease control centers and laboratory management. The application of laboratory information management system for disease control and prevention will play an active role in promoting the development and management of CDC laboratories.