Abstract: Objective　To analyze the relationship between integrons distribution and antibiotic resistance of common pathogens isolated in a community hospital and to provide evidence for appropriate administration of antibiotics. Methods　VITEK-AMS was employed for identification of isolates, seventy six isolates were tested for antibiotic resistance by Kirby - Bauer methods. ESBLs positive bacteria were selected by double-disk synergy test and the distribution of integrons were detected by PCR. Results　A total of 76 strains were isolated in the community hospitals, the majority of which (61) were Gram-negative bacteria, predominated by IEscherichia coli/I (24) and IKlebsiella pneumoniae/I (19). Most of the gram positive bacteria (15) were Staphylococcus epidermidis (10). Among the 76 strains, ClassⅠand Ⅱ integrons were detected. The positive rate of ClassⅠintegron was 44.7% (34/76), which mainly distributed in Gram-negative bacteria, and most commonly in IKlebsiella pneumoniae/I, accounting for 47.1% of all the detected integrons (16/34). Class Ⅱ integrons was detected in 5 strains of isolates with the positive rate of 6.5% (5/76), mainly distributing in IKlebsiella pneumoniae/I (3),too. More than 40.0% of the isolates were resistant to commonly used antibiotics, and the isolates with integrons and ESBLs showed multi-drug resistance. Most of strains of IEscherichia coli/I and IKlebsiella pneumoniae/I were resistant to -lactams with the resistant rates of 46.0% (11) and 90.0% (17), respectively, to which followed by quinolone, aminoglycoside, and amphenicols, with the average resistance rate of above 49%.Conclusion　The predominant strains isolated in the community hospital were Gram negative IEscherichia coli/I and IKlebsiella pneumoniae/I, mostly presenting with class Ⅰ integron distribution. Most isolates were resistant to commonly used antibiotics, and the drug resistance was correlated with the presence of integrons.