马瑞, 边国林, 许国章, 董红军, 周绍英, 倪红霞. 浙江省宁波市小月龄婴儿麻疹高发原因分析[J]. 疾病监测, 2008, 23(5): 308-310. DOI: 10.3784/j.issn.1003-9961.2008.5.308
引用本文: 马瑞, 边国林, 许国章, 董红军, 周绍英, 倪红霞. 浙江省宁波市小月龄婴儿麻疹高发原因分析[J]. 疾病监测, 2008, 23(5): 308-310. DOI: 10.3784/j.issn.1003-9961.2008.5.308
MA Rui, BIAN Guo-lin, XU Guo-zhang, DONG Hong-jun, ZHOU Shao-ying, NI Hong-xia. Cause analysis of high incidence of measles in infants at a young age in Ningbo[J]. Disease Surveillance, 2008, 23(5): 308-310. DOI: 10.3784/j.issn.1003-9961.2008.5.308
Citation: MA Rui, BIAN Guo-lin, XU Guo-zhang, DONG Hong-jun, ZHOU Shao-ying, NI Hong-xia. Cause analysis of high incidence of measles in infants at a young age in Ningbo[J]. Disease Surveillance, 2008, 23(5): 308-310. DOI: 10.3784/j.issn.1003-9961.2008.5.308

浙江省宁波市小月龄婴儿麻疹高发原因分析

Cause analysis of high incidence of measles in infants at a young age in Ningbo

  • 摘要: 目的 了解宁波市小月龄婴儿麻疹高发成因,为探讨降低小月龄婴儿麻疹发病免疫策略提供依据。方法 收集2004-2007年麻疹疫情资 料并分析;同时采用血清流行病学方法进行麻疹母传抗体研究。结果 麻疹流行特征发生明显变化,出现周岁内婴儿和成人2个发病高峰,尤其 是8月龄及8月龄至1岁麻疹发病年龄构成比逐年上升。在调查的174例8月龄至1岁婴儿中,有146例未及时接种麻疹疫苗,占83.9%。0~8月龄 婴儿麻疹抗体阳性率随着月龄的增长呈趋势性下降,6月龄和8月龄抗体阳性率分别只有4.1%和0.8%,几何平均滴度倒数 (GMRT)分别为4.2和 1.6。结论 麻疹母传抗体下降,6月龄和8月龄婴儿抗体阳性率很低,几乎无保护作用。麻疹疫苗接种不及时和免疫空白也是小月龄婴儿麻疹发 病高发的原因。

     

    Abstract: Objective The study was conducted to uncover the cause that precipitated the high incidence of measles in infants at a young age in Ningbo, providing evidence for the development of measles immunization strategies aiming to reduce the incidence of young infant measles. Methods Analyze was made upon the data of measles epidemic from 2004 through 2007. Maternally derived antibodies were analyzed using serological epidemiological approaches. Results Significant changes in epidemiological characteristics of measles were observed. Two peaks of incidence were noticed in infants less than one year of age and adults. In particular, those less than eight-month-old and eight-month-old to one-year-old of age had amounted to an increasing proportion in the age distribution. It was found that measles vaccination was not given in a timely manner to 146 out of 174 investigated infants (83.9%) who were aged 8 to 12 months. A declining positive rate of measles antibodies was noticed among infants aged 0 to 8 months in proportion to their ages, the rates for 6-month-olds and 8- month-olds being merely 4.1% and 0.8%, and GMRT 4.2 and 1.6, respectively. Conclusion Maternally derived measles antibodies reduce with the growth of infants. Therefore, 6-month-old and 8-month-old infants have too low antibody levels to protect them from measles. Inappropriate and inadequate vaccination is one of the causes that led to the high incidence of measles in infants at a young age in Ningbo.

     

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