Abstract: Objective　The study was conducted to investigate the epidemiological characteristics of injury and related knowledge, attitude and practice in adult residents in Hangzhou. Methods　A cluster randomized sample of 2000 subjects from 15 to 69 years of age was surveyed for injury related knowledge in Hangzhou using questionnaires from April to June in 2006.Results　The general awareness rate of injury was 72.83%, slightly higher in urban areas than in rural ones. Risk behaviors were present in 80.97% of urban adults and 88.05% of rural adults last year. However, 77.99% of urban adults and 86.58% of rural adults were willing to get rid of their risk behaviors. The proportion of 2.90% of urban adults and 6.75% of rural adults reported to have been injured in the past year. Conclusion　The incidence of injury was significantly higher in the urban areas without gender discrimination. The main causes included traffic accidents, falling, stabs and blunt injuries.