Abstract: ObjectiveTo realize the linkage of national internet based-infectious diseases reporting system with hospital information system (HIS), the direct extraction of infectious diseases report cards/death report cards and the report of infectious diseases data, and establish corresponding management standards and authentication procedures. MethodsThe interface and flow sheets of HIS were reformed in 3 hospitals during the pilot study. Web Service was used as the interface for data exchange. The quality of uploaded data was monitored by the database log. ResultsThree hospitals realized the automatic reporting of infectious diseases cases and death cases during the pilot study. ConclusionThe application of the technique used in this pilot study to link national internet based infectious diseases reporting system with HIS could provide the reference for the linkage of the diseases reporting system in the country, and this pilot study could provide the technical support for the improvement of the quality of infectious diseases and death case reporting.