Abstract: ObjectiveTo investigate the current status and incidence pattern of ISalmonella/I infection in Beijing, find out the change on the serotype and drug resistance spectrum of ISalmonella/I. MethodsAccording to the case definition, the stool samples were taken from the diarrhea patients who made the first visit to hospital to conduct serological and drug resistance tests. ResultsIn the summer of 2008, 38 strains of ISalmonella/I were detected in 6 hospitals with the positive rate of 4.83% (38/786). More cases occurred in young adults and the male to female ratio was 1.9∶1. Clinical symptoms included diarrhea, fever, nausea and vomiting. Eleven serotypes were found for 38 strains of ISalmonella/I. The predominating strain was ISalmonella enteritidis/I, followed by ISalmonella typhimurium./I All strains were sensitive to Ceftazidime, Cefotaxime, Cefepime, and the resistance rate to Nalidixic Acid was 65.69%. ConclusionThe clinical feature of diarrhea caused by ISalmonella/I infection is obvious, which is favorable for the case detection. Drug resistance surveillance could facilitate the rational use of antibiotics.