Abstract: ObjectiveTo analyze the risk factors of severe cases of hand foot and mouth disease (HFMD) in Zhejiang province. MethodsRetrospective analysis of HFMD cases was conducted by completing questionnaires in household interviews, and the data was statistically analyzed by logistic regression with SPSS 13.0 software. ResultsThe single-variate logistic regression analysis indicated that 12 factors had statistical significance which included age, occupation, fever, fever feature, bad mental status, vomiting, convulsion, proneness to eclampsia, extremity tremble, ecphysesis, high-WBC and EV71 infection. Multivariate logistic regression analysis indicated that EV71 infection, sustained fever, bad mental status, vomiting and convulsion were the risk factors. ConclusionEarly monitor on the risk factors of severe cases of HFMD and heteropathy should be conducted to reduce the case-fatality.