Abstract: ObjectiveTo analyze the epidemiological features of leptospirosis in Liping. MethodsDescriptive analysis was conducted on the data of leptospirosis epidemic in Liping from 2001 to 2008. ResultsA total of 127 leptospirosis cases with 28 deaths were reported in Liping during this period, the average annual morbidity was 3.18/lakh, the mortality was 0.70/lakh, and the case-fatality was 22.05%. The differences on morbidity and mortality in each year had statistical significance 2=.82,P=0.0000； 2=25.87, P=0.0005). The cases in students and farmers accounted for 96.06% of the total cases (122/127). ConclusionLiping county is the endemic area of leptospirosis, students and farmers are the mostly affected population. It is suggested to enhance the surveillance of leptospirosis in high incidence season and take comprehensive prevention and control measures including health education, deratization and vaccination to control the epidemic of leptospirosis and reduce the case-fatality.