Abstract: ObjectiveTo determine the situation of infection and subtype distribution associated with human papillomavirus(HPV) among female visitors to the gynecologic clinic of Lishui Peoples Hospital. MethodsCervical swabs collected from 246 patients from October 2006 to June 2007 were subject to gene-chip genetic detection invovling 23 genotypes of HPV. RseultsA total of 125 (50.8%) out of 246 women were identified as HPV-positive, including 54 (21.9%) of HPV-16, 21 (8.5%) of HPV-58 and 50 (20.3%) of others. Thirty-nine subjects were found to have been infected with two or more subtypes of HPV (15.8%), and 86 with one sole subtype (35.0%). Meanwhile, 39 HPV-positive patients were identified among 55 subjects that had cervical intraepithelial neoplasia (CIN), 11 HPV-positive ones among 12 with cervical cancer, and 11 HPV-positive ones among 13 with cervical condyloma acuminata. ConclusionIt is key to prevention and control of HPV infection in conjunction with appropriate management of CIN, which plays a significant part in the management of cervical cancer.