Abstract: ObjectiveTo analyze the changing trends of the prevalence situation of HIV/AIDS in Fengtai district, Beijing from 1990 to 2008. MethodsA total of 761 HIV/AIDS individual cases were statistically analyzed. ResultsFrom 1990 to 2008, a total of 761 HIV/AIDS cases were reported in Fengtai district, including 604 HIV cases and 157 AIDS ones. Gender distribution revealed 78.84% of males and 21.16% of females. The major transmission route was sexual contract, accounting for 61.50%. Increase in the number of cases infected through sexual activities was noticed since 2005, especially in the proportion of homosexual transmission. In contrast, infections via blood donation and blood/blood product transfusion had reduced. ConclusionRapid development of the epidemic of AIDS was currently noticeable in Fengtai district, spreading from high-risk population to the general, and homosexual contact became the major route of transmission. Therefore, greater effort should be made to strengthen the AIDS prevention and control in this risk group.