Abstract: Retrospective study was conducted on clinical characteristics and laboratory data of 250 cases of hemorrhagic fever with renal syndrome (HFRS) in Xiaoshan district of Hangzhou. The HFRS cases occurred sporadically all the years round, and were mainly distributed among young males (migrant workers), followed by students. The incidence was with two peaks (one during March-May, another during September-November), the cases in the two periods accounted for 35.34% and 56.18% of the total respectively. Up to 61.70% of the cases had direct and indirect rodent contact history. HFRS-IgM detection is highly specific and sensitive, which could be used in early diagnosis of HFRS.