Abstract: Objective To understand the epidemiological characteristics and trend of rubella in Wenzhou, provide scientific evidence for rubella prevention and control. Methods Descriptive epidemiological analysis was conducted on the data of rubella cases in Wenzhou from 2004 to 2009, which were obtained from national disease reporting information system and public emergency reporting system. Results A total of 12 401 rubella cases were reported during this period with the average annual incidence of 27.37/lakh. The disease occurred with obvious seasonality and the peaks were in late spring and early summer. The highest incidence was reported in adolescents aged 15-19 years. Students, especially the students in rural area, was the population mostly affected. Conclusion The rubella epidemic in Wenzhou is serious, it is necessary to carry out rubella immunization practically in order to increase the rubella vaccination coverage and reduce the incidence of rubella.