Abstract: Objective To study the extensively drug resistant mechanisms of Klebsiella pneumoniae and discuss the clinical treatment strategies. Methods The isolate was identified by Vitek-compact system, the drug susceptibility test was conducted by K-B method, and KPC-2 gene was detected by Hodge test and polymerase chain reaction (PCR), then sequenced, and the treatment of the patient was investigated. Results The strain was resistant to all antibiotics used in routine drug susceptibility test except polymyxin and minocycline. The inhibition zone diameter of fosfomycin added later was 20mm. In synergistic drug susceptibility test, no synergistic antimicrobial activity was found between polymyxin, minocycline, fosfomycin and imipenem. Hodge test was positive; KPC-2 gene was detected by PCR and the sequence was consistent with AF297554 in GenBank. After treatment for one month, no extensively drug resistant Klebsiella pneumoniae strain was detected from the patients. Conclusion It is necessary to strengthen the monitoring of extensively drug resistant Klebsiella pneumoniae and improve the awareness of extensively drug resistant bacteria to facilitate the prevention and treatment of infectious disease.