吴春利, 程小雯, 王昕, 吕星, 阳帆, 房师松, 吴平芳. 2009年广东省深圳市B型流感病毒系统进化及分子变异分析[J]. 疾病监测, 2011, 26(6): 442-445. DOI: 10.3784/j.issn.1003-9961.2011.06.008
引用本文: 吴春利, 程小雯, 王昕, 吕星, 阳帆, 房师松, 吴平芳. 2009年广东省深圳市B型流感病毒系统进化及分子变异分析[J]. 疾病监测, 2011, 26(6): 442-445. DOI: 10.3784/j.issn.1003-9961.2011.06.008
WU Chun-li, CHENG Xiao-wen, WANG Xin, LV Xing, YANG Fan, FANG Shi-song, WU Ping-fang. Phyletic evolution and molecular variation of influenza B viruses in Shenzhen, 2009[J]. Disease Surveillance, 2011, 26(6): 442-445. DOI: 10.3784/j.issn.1003-9961.2011.06.008
Citation: WU Chun-li, CHENG Xiao-wen, WANG Xin, LV Xing, YANG Fan, FANG Shi-song, WU Ping-fang. Phyletic evolution and molecular variation of influenza B viruses in Shenzhen, 2009[J]. Disease Surveillance, 2011, 26(6): 442-445. DOI: 10.3784/j.issn.1003-9961.2011.06.008

2009年广东省深圳市B型流感病毒系统进化及分子变异分析

Phyletic evolution and molecular variation of influenza B viruses in Shenzhen, 2009

  • 摘要: 目的 了解2009年深圳市B型流感病毒的系统进化及分子变异情况。 方法 对2009年深圳市分离的B型流感病毒的时间分布进行统计分析,并通过MEGA等软件对其HA1基因的系统进化及分子变异情况进行研究。 结果 深圳市2009年1-10月均有B型流感病毒流行,3-5月为流行高峰;Victoria系分支D的毒株是优势流行株;与2008 - 2009年度的国际疫苗株相比,Victoria和Yamagata系的HA1分子在其抗原决定簇区均出现了多个氨基酸位点的变异。 结论 2009年深圳市B型流感病毒的流行时间长,一些氨基酸位点的变异并没有导致一个新流行株系的形成。

     

    Abstract: Objective To study the phyletic evolution and molecular variation of influenza B viruses in Shenzhen in 2009. Methods The time distributions of the isolates influenza B viruses were analyzed. The phyletic evolution and molecular variation analysis of their HA1 genes were conducted by MEGA program. Results The time distributions of isolates of influenza B viruses indicated that the viruses circulated from January to October in 2009, which peaked during March-May. The virus in clade D of Victoria lineage was predominant. Compared with the viruses of influenza vaccines for 2008 - 2009 season, partial mutations of antigenic determinants in HA1 were detected in Victoria and Yamagata lineages. Conclusion The results indicated that the long time circulation of influenza B viruses was found in Shenzhen in 2009. The partial mutations detected in two lineages didnt resulted in the emerging of new circulating virus strains

     

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