莱姆病螺旋体的转移感染和致病机制

Mechanism of infection transmission and pathogenesis of Borrelia burgdorferi

摘要: 本文主要就莱姆病螺旋体从蜱到宿主动物的转移感染以及在宿主体内存活并致病的机制进行了的阐述,包括螺旋体在蜱内定居以及感染宿主动物过程中蛋白的变化及作用;螺旋体在宿主体内致病的各种机制(病原体本身的作用、免疫逃避、细胞因子的作用、自身免疫)。

Abstract: The paper describes the mechanism of transmission of Borrelia burgdorferi from ticks to host animals and pathogenesis in host animals, including the colonizing of B. burgdorferi in ticks, the change and role of its proteins in infecting host animals and all the pathogenic mechanisms of B. burgdorferi in host animals (self role of pathogen, immune evasion, function of cytokines and autoimmunity).