Abstract: Objective To understand the epidemiological characteristics of public health emergency in Tibet from 2004 to 2010, provide evidence for the prevention and control of public health emergency. Methods Descriptive epidemiological analysis was conducted on the incidence data of public health emergency in Tibet during this period. Results A total of 476 public health emergencies were reported. Communicable disease epidemics accounted for the largest proportion (96.2%), followed by food poisoning events (3.8%). The public health emergencies mainly occurred during April-June and during September-November in a year. Schools were the major sites in which public health emergencies occurred, the events occurred there accounted for 76.5% of the total. Conclusion It is necessary to establish and improve the predicting and warning system, strengthen the response support system and improve the response system to prevent public health emergency effectively. The majority of the public health emergencies occurred in schools in Tibet, which posed great threat to the students' health. The strategies for public health emergency prevention and control should be developed