Abstract: Objective To analyze the epidemic pattern and characteristics of AIDS in Inner Mongolia, and provide evixdence for the future prevention and control of AIDS. Methods The incidence data of HIV/AIDS reported in Inner Mongolia from 1996 to 2010 were collected to conduct statictical analysis by using Excel 2007 and SPSS 15.0 software. Results The incidence of HIV/AIDS was in an upward trend in Inner Mongolia, The cases were mainly distributed in Hohhot and Baotou. The sexual transmission was the major route. The cases were mainly detected by pre-operation examination and the screening in detained people. Conclusion The incidence of HIV/AIDS continued to increase in Inner Mongolia. Although some change was observed in the disease incidence, the incidence was still low. It is important to develop effective measures according to new characteristics of AIDS epidemic and strengthen the prevention and control of the disease to minimize the spread of AIDS.