Abstract: Objective To study the morbidity, mortality characteristics and incidence trend of malignant tumor in Huzhou and provide evidence for the development of prevention and control measures. Methods The surveillance data of malignant tumor from 2006 to 2010 were collected from 2 surveillance sites in Huzhou and classified according to the ICD-10 to conduct analysis on morbidity and mortality, age distribution and influence on life expectancy of malignant tumor. Results The average morbidity of malignant tumor was 258.35/lakh and the mortality was 163.64/lakh, which were higher in males than in females. The first 5 cancers with high morbidity were lung cancer, stomach cancer, colon cancer, liver cancer and breast cancer and the first 5 cancer death causes were lung cancer, stomach cancer, liver cancer, colon cancer and esophageal cancer. The morbidity and mortality of malignant tumor increased with age, the average age when the disease occurred was 62 years and the average age when death occurred was 67 years, which indicated that the prevention and control in old people should be strengthened. Close attention should be paid to the prevention and control of leukemia in adolescents. The first 5 cancer causes for life lost were lung cancer, liver cancer, stomach cancer, leukemia and colon cancer, which was inconsistent with the first 5 cancer death causes. Conclusion Malignant tumor has become the serious threat to the people's life quality in Huzhou, It is necessary to strengthen the multi sectoral cooperation to develop feasible prevention and control measures, conduct targeted health education and improve early screening to reduce the morbidity and mortality of malignant tumor.