吴莲凤, 陈栎江, 周铁丽. 大肠埃希菌感染的临床分布及耐药特性研究[J]. 疾病监测, 2011, 26(11): 903-905,922. DOI: 10.3784/j.issn.1003-9961.2011.11.020
引用本文: 吴莲凤, 陈栎江, 周铁丽. 大肠埃希菌感染的临床分布及耐药特性研究[J]. 疾病监测, 2011, 26(11): 903-905,922. DOI: 10.3784/j.issn.1003-9961.2011.11.020
WU Lian-feng, CHEN Li-jiang, ZHOU Tie-li. Clinical distribution of Escherichia coli infection and its drug resistance[J]. Disease Surveillance, 2011, 26(11): 903-905,922. DOI: 10.3784/j.issn.1003-9961.2011.11.020
Citation: WU Lian-feng, CHEN Li-jiang, ZHOU Tie-li. Clinical distribution of Escherichia coli infection and its drug resistance[J]. Disease Surveillance, 2011, 26(11): 903-905,922. DOI: 10.3784/j.issn.1003-9961.2011.11.020

大肠埃希菌感染的临床分布及耐药特性研究

Clinical distribution of Escherichia coli infection and its drug resistance

  • 摘要: 目的 通过对浙江省温州医学院附属第一医院近5年临床分离大肠埃希菌的临床分布和耐药特性分析,为临床合理利用抗菌药物和减少ESBLs的产生提供依据。 方法 回顾性调查2006-2010年该院住院患者标本分离的657株大肠埃希菌,使用VITEK-60全自动微生物分析仪专用药敏检测卡及K-B琼脂扩散法做药敏实验,对其临床分布及耐药情况进行总结分析。 结果 5年间分离出657株大肠埃希菌,各类感染标本中的分离率以尿液标本占首位,为47.5%(312株)。所检出的大肠埃希菌主要来源于重症监护病房(ICU)、普外科等科室,超过总分离菌株的60%,温州医学院附属第一医院产ESBLs大肠埃希菌的检出率从2006年的54.5%增高到2010年的70.7%(P0.05),且2006-2010年该院大肠埃希菌对多种抗菌药物的耐药率都有增高趋势,尤以对三、四代头孢菌素的增幅更为明显。ESBLs阳性株对氨苄西林、头孢唑啉、头孢曲松等11种药物的耐药率均高于ESBLs阴性株。 结论 大肠埃希菌所致感染日趋严重,耐药率逐年升高,产ESBLs大肠埃希菌的检出率也呈逐年增高趋势,且表现多重耐药,临床应加强对此类细菌的监测。

     

    Abstract: Objective To investigate clinical distribution of Escherichia coli isolation and its drug resistance in our hospital from 2006 to 2010 and provide evidence for the rational clinical drug use and reduction of ESBLs producing. Methods Retrospective survey was carried out on the clinical distribution of the Escherichia coli strains isolated during this period and drug susceptibility test was conducted by using VITEK-60 automatic microbio analyzer and K-B agar diffusion method. Results Totally 657 strains of Escherichia coli were isolated during this period, 312 strains were isolated from urine samples, accounting for 47.5%. The strains were mainly isolated in ICU and surgical wards, accounting for 60%. The isolation rate of ESBLs-positive Escherichia coli increased from 54.5% in 2006 to 70.7% in 2010 (P0.05). The resistance rates of Escherichia coli to commonly used antibiotics were in upward trend, especially for the 3rd and 4th generation cephalosporin. The drug resistance rates of ESBLs-positive strains to 11 antibiotics, including ampicillin, cefazolin and ceftriaxone, were higher than ESBLs-negative strains. Conclusion Escherichia coli infection is more serious than before, the multi drug resistance rates to commonly used antibiotics is in increase, and the detection rate of ESBLs producing Escherichia coli is also in increase. It is necessary to strengthen the clinical surveillance of the pathogens.

     

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