Abstract: Objective To understand the epidemiological characteristics of hand, foot and mouth disease(HFMD) in Hongkou District, Shanghai and discuss the prevention and control measures. Methods Statistical analysis was conducted on the incidence data of HFMD in Hongkou from 2005 to 2011. Results The average annual incidence of HFMD was 31.44/lakh during this period. The annual incidence peak was during May-July. The cases in age group 7 years accounted for 95.08% of the total cases. Most cases were children in and outside child care settings, accounting for 93.68%. The male to female ratio of the cases was 1.44:1. Jiangwan township, Liangcheng and Guangzhong communities ranked first 3 for their case numbers reported. The major pathogens were Cox A16 and EV71. Conclusion The incidence of HFMD had obvious age, gender and seasonal differences. It is essential to strengthen the multi-sectoral cooperation, conduct HFMD surveillance/effective response and carry out targeted health education to control the spread of HFMD.