Abstract: Objective To predict the incidence of scarlet fever with epidemic control chart and provide scientific evidence for the prevention and control of the disease. Methods The epidemic control chart of scarlet fever was made by setting upper limit line of the incidence on the basis of the maximum monthly incidence and the median line on basis of the median of the monthly incidence, then the incidence curve of the disease in the previous 2 months before predicting year was drawn on the chart to predict the incidence trend and intensity. Results The seasonality of scarlet fever incidence was obvious with two peaks during May-June and during December-January. It is predicted that scarlet fever epidemic might occur in 2012. Conclusion Epidemic control chart is suitable to predict the incidence of the disease with obvious seasonality, but it should be used with caution to ensure the prediction effectiveness and quality.