Abstract: Objective To understand the awareness of hepatitis C related knowledge in general population in Yanbian and provide evidence for the health education about hepatitis C. Methods The questionnaire survey about basic knowledge of hepatitis C and its prevention and treatment was conducted among 8000 residents in Yanbian. Results Totally 7987 valid questionnaires were returned. Among the subjects surveyed, 3452 (43.22%) were aware of hepatitis C. The correct answer rate of hepatitis C related questions was 26.56%. The differences on the correct answer rate among different groups of people were statistically significant (P0.05). The correct answer rate was higher in people with higher educational level and in females than in males, so were the rate in age group 30-39 and Han people. The awareness rate of basic knowledge about hepatitis C was40%. Broadcast of radio and television were the main channel for people to know the knowledge about hepatitis C prevention and treatment. Conclusion The awareness of hepatitis C related knowledge was not high in general population in Yanbian, it is necessary to strengthen the health education about hepatitis C among them.