马瑞, 许国章, 潘兴强, 李晓海, 方挺. 国产冻干水痘减毒活疫苗的免疫原性及接种1年后免疫持久性观察[J]. 疾病监测, 2012, 27(8): 601-603. DOI: 10.3784/j.issn.1003-9961.2012.8.006
引用本文: 马瑞, 许国章, 潘兴强, 李晓海, 方挺. 国产冻干水痘减毒活疫苗的免疫原性及接种1年后免疫持久性观察[J]. 疾病监测, 2012, 27(8): 601-603. DOI: 10.3784/j.issn.1003-9961.2012.8.006
MA Rui, XU Guo-zhang, PAN Xing-qiang, LI Xiao-hai, FANG Ting. Observation on immunogenicity of domestic freeze-dried live attenuated varicella vaccine and immunity persistence one year after vaccination[J]. Disease Surveillance, 2012, 27(8): 601-603. DOI: 10.3784/j.issn.1003-9961.2012.8.006
Citation: MA Rui, XU Guo-zhang, PAN Xing-qiang, LI Xiao-hai, FANG Ting. Observation on immunogenicity of domestic freeze-dried live attenuated varicella vaccine and immunity persistence one year after vaccination[J]. Disease Surveillance, 2012, 27(8): 601-603. DOI: 10.3784/j.issn.1003-9961.2012.8.006

国产冻干水痘减毒活疫苗的免疫原性及接种1年后免疫持久性观察

Observation on immunogenicity of domestic freeze-dried live attenuated varicella vaccine and immunity persistence one year after vaccination

  • 摘要: 目的 观察国产冻干水痘减毒活疫苗的免疫原性及持久性。 方法 选择119名7~13岁儿童分为两组,分别接种国产和进口冻干水痘减毒活疫苗,采用血清抗体膜免疫荧光法测定血清中的抗水痘病毒抗体水平。 结果 接种国产疫苗和进口对照疫苗6周后,抗体几何平均滴度分别为1∶160.7和1∶204.0,免疫成功率分别为96.7%和100%,两组免疫成功率和抗体几何平均滴度差异均无统计学意义(P分别为0.596和0.496,);接种国产疫苗1年后抗体水平显著低于接种6周后的抗体水平(P0.001)。 结论 国产疫苗与进口对照疫苗具有同样良好的免疫原性,但抗体水平会随着时间的延长而降低。

     

    Abstract: Objective To evaluate the immunogenicity and immunity persistence of domestic freeze-dried varicella attenuated live vaccine (VarV-Fd). Methods Totally 119 children aged 7-13 years were recruited in Ningbo and then divided into two groups. Domestic VarV-Fd and imported VarV-Fd were vaccinated respectively for the children in two groups and serum antibody levels to varicella-zoster virus were detected by antibody membrane immune-fluorescence assay. Results Six weeks after vaccination, the antibody geometric mean titer was 1∶160.7 in children receiving domestic VarV-Fd and 1∶204.0 in children receiving imported VarV-Fd, the difference had no statistical significance (P=0.596). The effective rates of both vaccines were 96.7% and 100%, the difference had no statistical significance (P=0.496). The antibody level of domestic VarV-Fd 1 year after vaccination was significantly lower than that 6 months after vaccination. (P0.001). Conclusion Both the domestic of VarV-Fd and imported VarV-Fd had good immunogenicity, but the immunity level by domestic VarV-Fd will decrease over time.

     

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