Abstract: Objective understand the prevalence of hyperuricemia in medical workers in Shaoxing and related factors, provide evidence for the health care of medical workers. Methods Totally 2273 medical workers aged 20-88 years were recruited in the study in 2012,they were divided into 5 gender specific age groups and blood uric acid (BUA) level, body mass index (BMI), routine blood indicators, thyroid function, renal function and blood lipid level were detected for them. Results The prevalence of hyperuricemia in males (12.97%) was higher than that in females (6.3%) (P0.01). The logistic regression analysis indicated that gender, fasting plasma glucose (FPG), triglyceride (TG), high density lipoprotein (HDL-C), creatinine (Cr) and BMI were correlated with the prevalence of hyperuricemia. In medical workers with hyperuricemia, the abnormal rates of TG, HDL-C, BMI and FPG were 40.9%, 30.2%, 22.0% and 10.7% respectively, while in medical workers without hyperuricemia, the abnormal rates of TG, HDL-C, BMI and FPG were 12.6%, 10.0%, 9.6% and 5.7% respectively, the difference was statistical significant (P0.01). Conclusion The gender specific difference on the prevalence of hyperuricemia in medical workers in Shaoxing was significant, the males were more likely to suffer from hyperuricemia. The people with hyperuricemia were prone to be overweight or obese. It is necessary to promote reasonable diet, physical activity and health examination.