梅玉发, 王喜云, 崔龙, 郑向梅, 刘海波. 湖北省十堰市59例柯萨奇病毒A组6型手足口病流行病学特征与临床特点分析[J]. 疾病监测, 2013, 28(12): 981-983. DOI: 10.3784/j.issn.1003-9961.2013.12.007
引用本文: 梅玉发, 王喜云, 崔龙, 郑向梅, 刘海波. 湖北省十堰市59例柯萨奇病毒A组6型手足口病流行病学特征与临床特点分析[J]. 疾病监测, 2013, 28(12): 981-983. DOI: 10.3784/j.issn.1003-9961.2013.12.007
MEI Yu-fa, WANG Xi-yun, CUI Long, ZHENG Xiang-mei, LIU Hai-bo. Epidemiological and clinical characteristics of 59 hand foot and mouth disease cases caused by Cox A6 in Shiyan, Hubei[J]. Disease Surveillance, 2013, 28(12): 981-983. DOI: 10.3784/j.issn.1003-9961.2013.12.007
Citation: MEI Yu-fa, WANG Xi-yun, CUI Long, ZHENG Xiang-mei, LIU Hai-bo. Epidemiological and clinical characteristics of 59 hand foot and mouth disease cases caused by Cox A6 in Shiyan, Hubei[J]. Disease Surveillance, 2013, 28(12): 981-983. DOI: 10.3784/j.issn.1003-9961.2013.12.007

湖北省十堰市59例柯萨奇病毒A组6型手足口病流行病学特征与临床特点分析

Epidemiological and clinical characteristics of 59 hand foot and mouth disease cases caused by Cox A6 in Shiyan, Hubei

  • 摘要: 目的 探讨柯萨奇病毒A组6型(coxsackievirus A6,Cox A6)手足口病的流行病学特征与临床特点,为该病的诊治与防控提供参考。方法 2012年10月至2013年9月,收集十堰市570例手足口病临床诊断病例标本,以实时荧光定量聚合酶链反应(real time RT-PCR)法进行手足口病病毒核酸检测并分型,对判定为Cox A6的手足口病确诊病例,采用描述流行病学方法进行流行病学特征与临床特点分析。结果 Cox A6在手足口病确诊病例的病原构成中居第3位(占13.41%,59/440);5岁以下儿童占100.00%,3岁以下占86.44%,散居、幼托儿童构成比为83.05%和16.95%,全市各县(市、区)全年均有发病,高峰期出现在10-11月,有1起聚集性疫情发生;所有病例在手、足、口或臀部出现皮疹,34.53%的病例出现发热,87.72%的病例出现口腔炎,26.32%的病例出现呼吸系统症状,3例白细胞计数偏高。结论 Cox A6肠道病毒可引起典型的手足口病及聚集性疫情,是手足口病的重要病原体之一,应加强监测与研究。

     

    Abstract: Objective To understand the epidemiological and clinical characteristics of hand foot and mouth disease(HFMD)caused by Cox A6,and provide reference for the diagnosis, treatment, prevention and control of HFMD. Methods A total of 570 specimens were collected from clinical diagnosed HFMD cases in Shiyan from October 2012 to September 2013, the identification and subtyping of the isolates were conducted with real-time fluorescent quantitative RT-PCR. The epidemiological and clinical characteristics of laboratory confirmed HFMD cases caused by Cox A6 were analyzed. Results In 440 laboratory confirmed HFMD cases, 59 were caused by Cox A6 (13.41%). All the cases were children aged5 years and 86.44% were children aged3 years. The cases in children outside child care settings and in child care setting accounted for 83.05% and 16.95% respectively. The cases occurred all the year round with the peak during October-November. One cluster of the cases was observed and all cases had rash on hand, foot, mouth or buttock, among these cases, 34.53% had fever, 87.72% had stomatitis, 26.32% had respiratory symptoms, 3 had high blood cell count. Conclusion Cox A6 is one of important pathogens to cause typical HFMD. It is necessary to strengthen the surveillance and research of Cox A6.

     

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