裘丹红, 翁坚, 沈伟伟, 陈喜凯, 华近, 林海江, 何纳. 2011年浙江省台州地区新发现HIV-1感染者分子流行病学调查[J]. 疾病监测, 2013, 28(12): 984-987. DOI: 10.3784/j.issn.1003-9961.2013.12.008
引用本文: 裘丹红, 翁坚, 沈伟伟, 陈喜凯, 华近, 林海江, 何纳. 2011年浙江省台州地区新发现HIV-1感染者分子流行病学调查[J]. 疾病监测, 2013, 28(12): 984-987. DOI: 10.3784/j.issn.1003-9961.2013.12.008
QIU Dan-hong, WENG Jian, SHEN Wei-wei, CHEN Xi-kai, HUA Jin, LIN Hai-jiang, HE Na. Molecular epidemiological survey among newly-diagnosed HIV-1 infected individuals in Taizhou, Zhejiang,2011[J]. Disease Surveillance, 2013, 28(12): 984-987. DOI: 10.3784/j.issn.1003-9961.2013.12.008
Citation: QIU Dan-hong, WENG Jian, SHEN Wei-wei, CHEN Xi-kai, HUA Jin, LIN Hai-jiang, HE Na. Molecular epidemiological survey among newly-diagnosed HIV-1 infected individuals in Taizhou, Zhejiang,2011[J]. Disease Surveillance, 2013, 28(12): 984-987. DOI: 10.3784/j.issn.1003-9961.2013.12.008

2011年浙江省台州地区新发现HIV-1感染者分子流行病学调查

Molecular epidemiological survey among newly-diagnosed HIV-1 infected individuals in Taizhou, Zhejiang,2011

  • 摘要: 目的 了解2011年浙江省台州地区新发现艾滋病病毒(HIV)感染者的基本情况以及不同HIV-1基因亚型的分布情况。方法 选取台州市2011年新发现未经抗病毒治疗的HIV感染者抗凝全血标本140份,提取血浆中的病毒RNA,通过RT-PCR扩增HIV-1 pol 区的蛋白酶基因全序列与反转录酶基因部分序列,使用HIV-Blast软件判定亚型。结果 2011年台州地区新发现的未经抗病毒治疗的HIV感染者男女性别比为3.24:1,感染者中92.86%为性传播感染,3.57%为注射毒品感染;共检测出5种HIV-1基因亚型,分别为CRF01_AE、CRF07_BC、CRF08_BC、B和C亚型。性传播感染人群中57.14%为CRF01_AE亚型,注射毒品人群中以CRF07_BC亚型为主。结论 台州地区艾滋病患者以性传播途径感染为主,HIV-1基因亚型呈多样性特点,CRF01_AE亚型流行于性传播感染人群,而CRF07_BC亚型流行于毒品注射感染人群。

     

    Abstract: Objective To understand the basic characteristics and HIV-1 subtype distribution among newly-diagnosed HIV infected individuals in Taizhou in 2011. Methods Blood samples were collected from 140 newly-diagnosed HIV infected individuals who received no antiviral therapy. RNAs were extracted and part of the pol gene which encoded the whole viral enzymes protease and part of reverse transcriptase was amplified with RT-PCR. HIV-Blast was used to confirm the subtypes of HIV-1. Results The male to female ratio of HIV infected persons was 3.24 :1. Up to 92.86% of HIV infections occurred through sexual contact, and 3.57% were through injecting drug use. Subtypes of CRF01_AE, CRF07_BC, CRF08_BC, B and C were detected, Totally 57.14% of the infections through sexual transmission were caused by subtype CRF01_AE and most infections through injecting drug use were caused by subtype C. Conclusion Sexual contact was the major HIV transmission route in Taizhou. The diversity of HIV-1 gene was observed. CRF01_AE was common in sexual transmitted infections and CRF07_BC was common in the infections through injecting drug use.

     

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