Abstract: Objective To understand the death level of injury and poisoning and related health hazard in residents in Ouhai district of Wenzhou, Zhejiang province, and provide evidence for the development of injury and poisoning prevention strategy. Methods The death causes in residents in Ouhai from 2010 to 2012 were classified according to the International Classification of Diseases, 10th revision (ICD-10) and software Death Reg-2005 was used to produce statistical tables for analysis. Result The average annual death rate of injury and poisoning was 48.24/lakh during this period, the standardized death rate was 39.81/lakh. The death rate was 56.79/lakh in males and 39.44/lakh in females. Accidental fall, traffic accident, suicide and drowning were major causes of injury and poisoning death, the cumulative proportion in all deaths was 83.62%. The potential years of life lost rate caused by injury and poisoning death was 6.30 . Conclusion Death caused by injury and poisoning has posed a great threaten to local people's health. It is necessary to effective prevention measures according to the characteristics of injury and poisoning death.