Abstract: Objective To understand the epidemiological characteristics of mumps in Zhoukou in recent 7 years and provide scientific evidence for developing control strategies. Methods Descriptive epidemiological analysis was conducted on the incidence data of mumps in Zhoukou from 2005 to 2011 collected from national disease reporting information system. Results A total of 7 998 mumps cases were reported in Zhoukou during this period, the average annual incidence was 11.43/lakh. The highest incidence in Fugou county was 30.81/lakh,which was 7.91/lakh in males and 3.51/lakh in females (P=0.0055), respectively. The incidence peak was during March-June (47.01%). The cases were mainly distributed in students (64.49%) and children in and outside child care settings (29.93%), and the cases in age groupConclusion The reported incidence of mumps in Zhoukou city was higher than that of mumps in other districts in Henan province in recent 7 years. It is necessary to conduct targeted prevention and control of mumps among risk population during the incidence peak period.