国产与进口流行性腮腺炎疫苗免疫后阳转率的Meta分析
Meta analysis on antibody positive conversion rate of domestic and imported mumps vaccines
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摘要: 目的 比较国产与进口流行性腮腺炎(腮腺炎)疫苗接种后的抗体阳转率,评价二者免疫学效果差异。 方法 检索 PubMed、《中国生物医学文献数据库》、《中国期刊全文数据库(CNKI)》、《万方数据库》,筛选国产与进口腮腺炎疫苗抗体阳转率比较的流行病学现场试验文献,对符合纳入标准的研究采用Review Manager 5.0进行Meta分析。 结果 共纳入8篇文献。Meta分析结果显示,国产组与进口组腮腺炎疫苗接种后的抗体阳转率差异无统计学意义(RR=0.97,95%CI为0.92~1.03,Z=1.03,P=0.30),其中国产腮腺炎单价疫苗与进口麻疹-流行性腮腺炎-风疹联合疫苗(MMR)的腮腺炎抗体阳转率差异无统计学意义(RR=0.99,95%CI为0.92~1.05,Z=0.41,P=0.68)、国产MMR疫苗与进口MMR疫苗的腮腺炎抗体阳转率差异无统计学意义(RR=0.96,95%CI为0.90~1.04,Z=1.02,P=0.31)。 结论 国产与进口腮腺炎疫苗接种后的抗体阳转率无明显区别。Abstract: Objective To compare the antibody positive conversion rate between domestic mumps vaccine and imported mumps vaccine to evaluate their immunogenicity. Methods The literatures about antibody conversion rate comparison of domestic and imported mumps vaccines were searched from PubMed, China Biology Medicine Disc, China National Knowledge Infrastructure database and Wanfang database to conduct a meta-analysis by using RevMan 5.0 software. Results Eight related papers were selected for the analysis and the result indicated that the difference in positive conversation rate after vaccination of domestic and imported mumps vaccines was not statistical significant (RR=0.97,95% CI: 0.92-1.03, Z=1.03, P=0.30), and the sub-group analysis showed that both domestic monovalent mumps vaccine and imported MMR vaccine induced positive conversion rates and domestic MMR vaccine and imported MMR vaccine induced positive conversion rates had no statistical significant differences(RR=0.99,95% CI: 0.92-1.05,Z=0.41, P=0.68; RR=0.96,95% CI: 0.90-1.04,Z=1.02,P=0.31). Conclusion There is no difference between domestic mumps vaccine and imported mumps vaccine in immunogenicity, and they all have satisfactory immune effect.
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