Abstract: Objective To understand the epidemiologic characteristics of plague in Guoqing district of Yushu prefecture, Qinghai province. Methods The analysis was conducted on the surveillance data of plague in this area during 2004-2010. Results A total of 11 Yersinia pestis strains were isolated in 2005, 2007 and 2010, and 104 F1 antibody positive serum samples were detected in 2005, 2007 and 2008. Conclusion Plague is spread constantly in animals in Yushu. It is still necessary to strengthen the surveillance of host animals of plague and make rapid response to plague epidemic in animals.