Abstract: Objective To understand the prevalence of schistosomiasis and evaluate the surveillance measure and control strategy in former transmission areas in Guangzhou, Guangdong province. Methods Oncomelania survey was made and dot immunogold filtration assay(DIGFA) was used to conduct screening among local and floating populations. The positive persons were confirmed by etiological examination(nylon pocket egg concentration method). Results No oncomelania was discovered. The DIGFA results were negative among local population, but the positive rate in floating population was 1.36%. In the following etiological examination, no schistosomiasis case was detected. Conclusion The achievement of transmission blocking of schistosomiasis in former transmission areas in Guangzhou are maintained well, but it is still necessary to strengthen the surveillance in these areas, especially among floating population.