谢忠杭, 张莹珍, 严延生, 洪荣涛, 王灵岚. 手足口病再次发病特征初探[J]. 疾病监测, 2013, 28(9): 735-739. DOI: 10.3784/j.issn.1003-9961.2013.9.011
引用本文: 谢忠杭, 张莹珍, 严延生, 洪荣涛, 王灵岚. 手足口病再次发病特征初探[J]. 疾病监测, 2013, 28(9): 735-739. DOI: 10.3784/j.issn.1003-9961.2013.9.011
XIE Zhong-hang, ZHANG Ying-zhen, YAN Yan-sheng, HONG Rong-tao, WANG Ling-lan. Preliminary study on recurrence with viruses causing hand foot and mouth disease[J]. Disease Surveillance, 2013, 28(9): 735-739. DOI: 10.3784/j.issn.1003-9961.2013.9.011
Citation: XIE Zhong-hang, ZHANG Ying-zhen, YAN Yan-sheng, HONG Rong-tao, WANG Ling-lan. Preliminary study on recurrence with viruses causing hand foot and mouth disease[J]. Disease Surveillance, 2013, 28(9): 735-739. DOI: 10.3784/j.issn.1003-9961.2013.9.011

手足口病再次发病特征初探

Preliminary study on recurrence with viruses causing hand foot and mouth disease

  • 摘要: 目的 初步探讨手足口病的再次发病特征,为深入调研和制定防控策略提供依据。 方法 运用 SAS 9.0 软件分析福建省2010-2012年通过《疾病监测信息报告管理系统》报告的手足口病监测信息。 结果 共报告手足口病卡片209 733张,其中再次发病卡片4192张、再发率20.39‰。当地或当月疫情流行强度越强再次发病现象越多;城市、男性病例更易再次发病。再次发病时间在首次发病后1年内的占68.08%(2854/4192)。再次发病的病原主要是肠道病毒71型(EV71)毒株(43/97),再次发病后可进展为重症病例(19/4192),其病死率与非再次发病间的差异无统计学意义(Fisher确切概率法,P=0.41)。存在同一病原反复感染、不同病原交叉感染导致的多次发病现象。 结论 本研究总体低估了实际疫情中的再次发病现象,应进一步加强疫情监测;首次发病年龄在4岁以下者,在其首次发病后的1年内应谨防其再次发病;再次发病后仍需警惕其病情重症化情况。

     

    Abstract: Objective To understand the incidence characteristics of recurrence with viruses causing hand foot and mouth disease (HFMD) and provide evidence for HFMD prevention and control. Methods The surveillance data of HFMD in Fujian province from 2010 to 2012 were analyzed by using SAS 9.0. Results A total of 209 733 HFMD cases were reported, in which 4192 were recurrence. The recurrence rate was 20.39‰. More recurrence occurred during the high incidence period, and in urban areas and in males. The intervals between the first infection and the second infection in 68.08% of the cases were less than 360 days. The major pathogen causing recurrence was EV71 (43/97), the recurrence had led to severe disease (19/4192), and the difference in case fatality between recurrence and the first infection had no statistical significance. Recurrence might caused by the same pathogen or by different pathogens. Conclusion The incidence of recurrence with viruses causing HFMD was underestimated in study. It is necessary to strengthen the surveillance of HFMD. Close attention should be paid to children aged <4 years who are more likely to be re-infected within 1 year after the first infection. When recurrence occurs, the prevention of severe disease should be considered.

     

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