杨丽萍, 刘彬辉. 60 g乙肝疫苗用于323例成人无应答者接种效果的观察[J]. 疾病监测, 2014, 29(4): 298-299. DOI: 10.3784/j.issn.1003-9961.2014.04.012
引用本文: 杨丽萍, 刘彬辉. 60 g乙肝疫苗用于323例成人无应答者接种效果的观察[J]. 疾病监测, 2014, 29(4): 298-299. DOI: 10.3784/j.issn.1003-9961.2014.04.012
YANG Li-ping, LIU Bin-hui. Observation on effect of hepatitis B vaccine at dosage 60 g in 323 adults without immunization response to previous vaccination[J]. Disease Surveillance, 2014, 29(4): 298-299. DOI: 10.3784/j.issn.1003-9961.2014.04.012
Citation: YANG Li-ping, LIU Bin-hui. Observation on effect of hepatitis B vaccine at dosage 60 g in 323 adults without immunization response to previous vaccination[J]. Disease Surveillance, 2014, 29(4): 298-299. DOI: 10.3784/j.issn.1003-9961.2014.04.012

60 g乙肝疫苗用于323例成人无应答者接种效果的观察

Observation on effect of hepatitis B vaccine at dosage 60 g in 323 adults without immunization response to previous vaccination

  • 摘要: 目的 探讨成人乙型病毒性肝炎(乙肝)疫苗接种后无应答者的免疫对策。方法 选择浙江省湖州市南浔区免疫无应答人群免疫前检测乙肝表面抗原(HBsAg)和乙肝表面抗休(抗-HBs)均阴性的健康人群,按0,1,3;0,1,6;0,1,12程序完成3 针20 g 重组酵母乙肝疫苗免疫后检测乙肝抗-HBs 几何抗体平均浓度(GMC)10 IU/L 的免疫失败者,接种1剂次60 g乙肝疫苗后1 个月,检测抗-HBs。结果 323 例免疫失败者完成再免后抗-HBs 阳性率为92.6%,GMC为835 IU/L。结论 成人乙肝疫苗接种后免疫失败者,通过加大乙肝疫苗剂量,再次接种1剂次60 g乙肝疫苗可大幅度提高抗-HBs 阳转率,效果优于再次接种10 g或20 g乙肝疫苗。

     

    Abstract: Objective To explore the immunization strategy in adults who have no response to hepatitis B vaccination. Methods Healthy people who were HBsAg and anti-HBs negative were selected, and 3 doses of hepatitis B vaccine at dosage 20 g were given to them at the schedule of 0, 1, 3 month, 0, 1, 6 month and 0, 1, 12 month respectively. Those with anti-HBs GMC10 IU/L detected after full series vaccination were given 1 dose of hepatitis B vaccine at dosage 60 g. One month later, anti-HBs detection was conducted for them. Results The anti-HBs positive rate was 92.6% in re-vaccinated people, and the anti-HBs GMC was 835 IU/L. Conclusion Re-immunization of hepatitis B vaccine at dosage 60 g could obviously increase the anti-HBs positive conversion rate in people who has no response to previous vaccination, and the effect is better than those of hepatitis B vaccine at dosage 10 g or 20 g.

     

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