Abstract: Objective To understand the antibody levels to Neisseria meningitides group A, C and W135 in healthy people in Suzhou, Jiangsu province and provide evidence for meningococcal disease prevention and control. Methods A total of 599 serum samples were randomly collected from age groups 0, 1, 3, 6, 10, 15, 20 and 40 years in Suzhou during 2011-2012.The antibodies to N. meningitides were detected by using enzyme-linked immunosorbent assay (ELISA). Results The antibody positive rate was 80.47% to N. meningitides group A, 74.12% to N. meningitides group C and 45.38% to N. meningitides W135. The positive rate to group A was lowest in age group 0 year (48.89%) and highest in age group 15 years (90.48%). The positive rate to group C was lowest in age group 0 year (48.89%) and highest in age group 6 years (88.24%). The positive rate to group W135 was lowest in age group 0 years (20.45%) and highest in age group 3 years (52.00%).The positive rate to group A was 79.59%o in males and 82.13% in females. The positive rate to group C was 71.43% in males and 79.23% in females. The positive rate to group W135 was 43.22% in males and 49.51% in females. The positive rate was 69.02% to group A. 69.02% to group C and 35.56% to group W135 in Changshu; The positive rate was 85.16% to group A, 75.00% to group C and 44.53% to group W135 in Kunshan. The positive rate was 86.16% to group A, 78.62% to group C and 57.86% to group W135 in Xiangcheng. Conclusion The antibody levels to N. meningitides group A and C were high in population in Suzhou. The antibody levels to N. meningitides group A, C and W135 were lowest in age group 0 year. The antibody level was high in areas with high vaccination coverage. The herd immunity to group W 135 was low.