Abstract: Objective To understand the serotypes and drug susceptibility of Salmonella as well as the clinical manifestation of Salmonella infection in Pinghu from 2009 to 2013. Methods The biochemical identification and serotyping of 91 Salmonella strains isolated were conducted and the drug susceptibility test was performed by using Merieux Alliance VITEK-2 Compact from French. Results Eleven serotypes were detected in the 91 Salmonella isolates, Paratyphi A and Salmonella typhi were the major serotypes of blood stream infection; Salmonella typhimurium and Salmonella enteritidis were the major serotypes of intestinal infection. Fever, pains, yellow watery stools were the main clinical symptoms of Salmonella infection. The drug sensitive rate of the Salmonella strains was 34.07% to Ampicillin, 36.26% to Piperacillin and 45.05% to Tetracycline. The Salmonella strains were sensitive to the third and forth-generation cephalosporins, quinolones and carbapenems (70%-100%). The drug resistant rates of 5 common serotypes of Salmonella to Ampicillin/sulbactam were obvious different. The resistant rates of Salmonella typhimurium and Salmonella enteritidis were 75.00% and 47.62%. The resistant rates of Paratyphi A, Salmonella typhi and Paratyphoid C were less than 20%. Conclusion Salmonella is one of the pathogens causing diarrhea in children under 7 years old, The serotypes of Salmonella varies by sources from which they are detected, and the drug resistances of Salmonella varies by their serotypes. It is necessary to strengthen the surveillance among the risk population. Salmonella is sensitive to most antibiotics, and cephalosporins or quinolones may be the first choice in clinical treatment.