孙军玲, 张静, 阚飙, 闫梅英, 常昭瑞. 2012年全国伤寒和副伤寒重点监测数据分析[J]. 疾病监测, 2014, 29(11): 875-879. DOI: 10.3784/j.issn.1003-9961.2014.11.009
引用本文: 孙军玲, 张静, 阚飙, 闫梅英, 常昭瑞. 2012年全国伤寒和副伤寒重点监测数据分析[J]. 疾病监测, 2014, 29(11): 875-879. DOI: 10.3784/j.issn.1003-9961.2014.11.009
SUN Jun-ling, ZHANG Jing, KAN Biao, YAN Mei-ying, CHANG Zhao-rui. Key surveillance for typhoid/paratyphoid fever in China, 2012[J]. Disease Surveillance, 2014, 29(11): 875-879. DOI: 10.3784/j.issn.1003-9961.2014.11.009
Citation: SUN Jun-ling, ZHANG Jing, KAN Biao, YAN Mei-ying, CHANG Zhao-rui. Key surveillance for typhoid/paratyphoid fever in China, 2012[J]. Disease Surveillance, 2014, 29(11): 875-879. DOI: 10.3784/j.issn.1003-9961.2014.11.009

2012年全国伤寒和副伤寒重点监测数据分析

Key surveillance for typhoid/paratyphoid fever in China, 2012

  • 摘要: 目的 了解2012年中国(未含香港、澳门、和台湾地区,以下同)伤寒和副伤寒国家监测点的优势菌型、菌株耐药变化情况以及脉冲场凝胶电泳(pulsed-field gel electrophoresis,PFGE)优势带型变化特征.方法 用描述流行病学方法对伤寒、副伤寒国家监测点2012年伤寒和副伤寒重点监测结果进行描述,并与法定报告数据进行比较和分析.结果 13个监测点伤寒和副伤寒总报告发病率为7.86/10万,其中实验室诊断病例(510例)中副伤寒占56.08%.重点监测显示: 13个监测点共分离出147株病原菌,阳性检出率为2.55%;分离的病原以甲型副伤寒沙门菌为主(占73.47%),显著高于法定报告数据中副伤寒的比例.不同监测点病原阳性检出率差异很大,病原构成比差异也很大.2012年伤寒、甲型副伤寒沙门菌株对萘啶酸和环丙沙星的耐药率均有所上升.PFGE分析表明,2012年伤寒沙门菌监测菌株出现了3种新的优势带型,而JKPX01.CN0001仍为甲型副伤寒沙门菌监测菌株的优势流行带型.结论 伤寒和副伤寒重点监测系统是法定报告的补充,监测点病原以甲型副伤寒为主,需阶段性地对该系统进行评估以保证监测质量.

     

    Abstract: Objective To understand the predominant serotypes, the change in drug resistance of Salmonella typhi and Salmonella paratyphi and the change of related pulsed-field gel electrophoresis (PFGE) pattern in surveillance areas in the mainland of China. Methods Descriptive epidemiological analysis was conducted on the surveillance data of typhoid/paratyphoid fever in key surveillance areas in China in 2012. The results were compared with those reported to national disease reporting information system. Results The overall incidence of typhoid/paratyphoid fever in 13 surveillance areas was 7.86/lakh. Among 510 laboratory confirmed cases, paratyphoid fever cases accounted for 56.08%, significantly lower than the national average level (63.14%). The surveillance results showed that 147 S. typhi and S. paratyphi strains were isolated. The positive detection rate was 2.55%. The predominated pathogen was S. paratyphi A, accounting for 73.47%. This proportion was much higher than that reported to national disease reporting information system. The positive detection rate and the pathogens detected varied with the surveillance area. The drug-resistance rates of S. typhi and S. paratyphi A to nalidixic acid and ciprofloxacin increased in 2012. PFGE analysis showed there were 14 patterns of S. typhi detected in 2012, in which 3 were new predominant patterns, while JKPX01. CN0001were still the predominant pattern of S. paratyphi A. Conclusion S. paratyphi A is the major pathogen in the surveillance areas. Surveillance for typhoid/paratyphoid fever in key areas can provide more information about the incidence of typhoid/paratyphoid fever in China, but the regular evaluation on the surveillance quality is needed.

     

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