吕勇, 周蕾, 耿兴义, 任瑞琦, 秦伟, 李群, 解少煜, 李开春, 张彦平, 向妮娟. 中国内地24例人感染H7N9禽流感儿童病例流行特征分析[J]. 疾病监测, 2015, 30(7): 570-573. DOI: 10.3784/j.issn.1003-9961.2015.07.011
引用本文: 吕勇, 周蕾, 耿兴义, 任瑞琦, 秦伟, 李群, 解少煜, 李开春, 张彦平, 向妮娟. 中国内地24例人感染H7N9禽流感儿童病例流行特征分析[J]. 疾病监测, 2015, 30(7): 570-573. DOI: 10.3784/j.issn.1003-9961.2015.07.011
LYU Yong, ZHOU Lei, GENG Xing-yi, REN Rui-qi, QIN Wei, LI Qun, XIE Shao-yu, LI Kai-chun, ZHANG Yan-ping, XIANG Ni-juan. Epidemiological characteristics of 24 children cases of influenza A (H7N9) virus infection in China[J]. Disease Surveillance, 2015, 30(7): 570-573. DOI: 10.3784/j.issn.1003-9961.2015.07.011
Citation: LYU Yong, ZHOU Lei, GENG Xing-yi, REN Rui-qi, QIN Wei, LI Qun, XIE Shao-yu, LI Kai-chun, ZHANG Yan-ping, XIANG Ni-juan. Epidemiological characteristics of 24 children cases of influenza A (H7N9) virus infection in China[J]. Disease Surveillance, 2015, 30(7): 570-573. DOI: 10.3784/j.issn.1003-9961.2015.07.011

中国内地24例人感染H7N9禽流感儿童病例流行特征分析

Epidemiological characteristics of 24 children cases of influenza A (H7N9) virus infection in China

  • 摘要: 目的 探讨人感染H7N9禽流感儿童病例的流行病学特征和临床表现,为防控人感染H7N9禽流感提供数据支持和决策依据。方法 以中国疾病预防控制信息系统报告的中国内地儿童病例为研究对象,分析其时间、空间和人群分布等流行病学特征及其临床表现。结果 截至2014年8月31日,中国内地共报告24例儿童病例。病例的发病高峰在2014年春季,主要分布在9个省份,广东省报告发病例数最多(11例)。其中7例仅有家养禽暴露史,12例有活禽市场暴露史,2例仅有确诊病例暴露史,3例无明确禽类、市场和病例暴露史。在5个省份共发现了7起涉及儿童病例的聚集性疫情。发病初期主要表现为流感样症状,6例出现肺炎,无重症和死亡病例。从发病到就诊、到使用达菲治疗、到治愈时间中位数分别为0、1和10 d。强化监测、密切接触者医学观察和流感样病例监测为病例主要发现途径。结论 儿童病例的发病时间、地区分布与成人病例相似,但临床主要表现为轻症病例,与成人病例不同。

     

    Abstract: Objective To understand the epidemiological and clinical characteristics of human infection with avian influenza A (H7N9) virus in children, and provide evidence for the prevention and control of H7N9 virus infection. Methods The data of children H7N9 virus infection cases reported through national disease reporting information system were used in this study to analyze their time, geographic and population distributions and their clinical characteristics. Results As of 31 August 2014,24 children cases of H7N9 virus infection were reported in 9 provinces in China. The case number was highest in Guangdong province (11 cases). The incidence curve showed an obvious peak in spring in 2014. Among the 24 cases, 7 had alive poultry exposures, 12 had alive poultry market exposures, 2 had contacts with confirmed H7N9 virus infection cases and 3 had no clear exposures mentioned above. Seven clustering of H7N9 infection cases in children were found in 5 provinces. The main manifestations of H7N9 virus infection at initial stage was influenza like symptoms. Pneumonia developed in 6 cases. No severe cases and deaths occurred. The medians of intervals between onset and medical care seeking, onset and treatment with oseltamivir, and onset and cure were 0 day, 1 day and 10 days. Strengthened surveillance and medical observation for close contacts were the main ways for the case finding. Conclusion The time and geographic distributions of H7N9 virus infections in children are similar to those in adults, but the children cases usually have milder symptoms compared with adult cases.

     

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