刘东林, 潘海燕, 张长桂. 2008-2013年江苏省东台市疑似预防接种异常反应监测情况分析[J]. 疾病监测, 2015, 30(7): 585-587. DOI: 10.3784/j.issn.1003-9961.2015.07.015
引用本文: 刘东林, 潘海燕, 张长桂. 2008-2013年江苏省东台市疑似预防接种异常反应监测情况分析[J]. 疾病监测, 2015, 30(7): 585-587. DOI: 10.3784/j.issn.1003-9961.2015.07.015
LIU Dong-lin, PAN Hai-yan, ZHANG Chang-gui. Surveillance for adverse events following immunization in Dongtai, Jiangsu,2008-2013[J]. Disease Surveillance, 2015, 30(7): 585-587. DOI: 10.3784/j.issn.1003-9961.2015.07.015
Citation: LIU Dong-lin, PAN Hai-yan, ZHANG Chang-gui. Surveillance for adverse events following immunization in Dongtai, Jiangsu,2008-2013[J]. Disease Surveillance, 2015, 30(7): 585-587. DOI: 10.3784/j.issn.1003-9961.2015.07.015

2008-2013年江苏省东台市疑似预防接种异常反应监测情况分析

Surveillance for adverse events following immunization in Dongtai, Jiangsu,2008-2013

  • 摘要: 目的 了解江苏省东台市免疫规划疫苗引起的疑似预防接种异常反应(AEFI)的特征,评价AEFI监测系统运转状况及预防接种的安全性。方法 对2008-2013年东台市各预防接种点报告的免疫规划疫苗相关AEFI监测情况进行描述性流行病学分析。结果 2008-2013年间共报告AEFI病例847例,发生率8.78/万剂次,年龄1周岁以上儿童发生率16.39/万剂次,1周岁内儿童发生率4.71/万剂次,两者差异有统计学意义(2=309.28,P0.05);白破(53.80/万剂次)、麻风(19.79/万剂次)、无细胞百白破(17.92/万剂次)分列发生率的前3位;一般反应的有806例,占95.16%,异常反应39例,占4.6%;病例年龄分布中0岁组占比最高,为35.30%,其次为1岁组,占28.81%;男女性别之比为1.48:1;发生时间间隔0~2天为728例,占85.95%。结论 东台市AEFI信息管理系统监测敏感性高,监测质量还需进一步提高;1周岁以上儿童比1周岁内的儿童易发生AEFI。

     

    Abstract: Objective To understand the incidence of adverse events following immunization (AEFI) in Dongtai, Jiangsu province,and evaluate the performance of AEFI surveillance system and vaccination safety. Methods Descriptive epidemiological analysis was conducted on the surveillance data of AEFI in Dongtai during 2008-2013. Results A total of 847 AEFI cases were reported, the overall incidence was 8.78 per 10 000 doses. The age specific incidence was 16.39 per 10 000 doses in children aged 1 year and 4.71 per 10 000 doses in children aged 1 year. The difference was statistical significant (2=309.28,P0.05). The first 3 vaccines with high incidences of AEFI were TD (53.80 per 10 000 doses), MR (19.79 per 10 000 doses), DTaP (17.92 per 10 000 doses). Among the AEFI cases, 806 were mild reactions (95.16%), 39 were serious reactions (4.6%). The cases in age group 1 year accounted for 35.30% and the cases in age group 1 year accounted for 28.81%. The male to female ratio of cases was 1.48:1. Up to 728 cases occurred within days after vaccination(85.95%). Conclusion The sensitivity of local AEFI surveillance system was high, but the surveillance quality still needs to be further improved.

     

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