Abstract: Objective To understand the spatial distribution of hepatitis A in Gansu province,2013,and provide evidence for hepatitis A prevention and control. Methods The incidence data of hepatitis A in Gansu were obtained from national disease reporting information system, and spatial statistic software was used to analysis the spatial autocorrelation and clustering of hepatitis A incidence. Results Reported hepatitis A incidence of Gansu in 2013 had spatial autocorrelation statistically (P 0.001). Local spatial autocorrelation analysis identified high-high pattern area (Jiuquan, Wuwei, Gannan, and part of Linxia) and low-low pattern area (Jiayuguan, Zhangye, part of eastern and southern Gansu) (P 0.05). SaTScan statistics results indicated that the mostly likely clustering of high hepatitis A incidence was in Liangzhou and surrounding counties (RR=2.580, P=0.001). Conclusion The spatial distribution of hepatitis A was not random in Gansu in 2013, the clustering of the disease were found in Wuwei, Linxia and Gannan, indicating hepatitis A surveillance should be strengthened in these areas.