Abstract: Objective To understand the age and sex specific incidence of gonococcal infection, sexually transmitted chlamydial infection and syphilis and related disease burden in China during the past 20 years. Methods The age and sex specific case number and morbidity of gonococcal infection, sexually transmitted chlamydial infection and syphilis were estimated by using Bayesian technique and related years of life lost (YLL), years lived with disability (YLD) and disability adjusted life year (DALY) were calculated. Results In 1990 the case number, standardized morbidity, death number, standardized mortality, DALY, standardized DALY, YLL, standardized YLL, YLD and standardized YLD of gonococcal infection, sexually transmitted chlamydial infection and syphilis in China were 10 291 090, 7042.486/lakh, 17 938, 1.281/lakh, 1 522 920 person years, 98.725 person years/lakh, 1 260 150 person years, 74.655 person years /lakh, 262 770 person years, and 24.071 person years/lakh, respectively. In 2010, the case number and YLD increased slightly, but the values of other indicators declined. The case number, standardized morbidity, death number, standardized mortality, DALY, standardized DALY, YLL, standardized YLL, YLD, and standardized YLD were 10 359 147, 6099.137/lakh, 2429, 0.182/lakh, 448 360 person years, 33.823 person years/lakh, 168 560 person years, 12.377 person years/lakh, 279 800 person years and 21.447 person years/lakh, respectively. Compared with 1990, in 2010, the gonococcal infection cases increased in age groyp 4 years, sexually transmitted chlamydial infection cases declined in age group 5-14 years and increased in age groups 50-69 years and 70 years. The morbidity of gonococcal infection was in decline. Except age group 5-14 years, the morbidity of syphilis increased in all the age groups. The standardized morbidity of the three sexually transmitted diseases showed a decline trend from 1990 to 2010. The death number in age group 5 years was highest compared with other age groups. Conclusion The morbidity of gonococcal infection, sexually transmitted chlamydial infection and syphilis in Chinese was in decline from 1990 to 2010. Reporting the age and sex specific disease burden can more accurately reflect the impact of sexually transmitted diseases in different populations and facilitate targeted prevention and control.