耿启彬, 赖圣杰, 余建兴, 张子科, 杨婉琪, 李中杰, 吴建国, 杨维中. 中国26省(直辖市、自治区)2011-2014年5岁以下儿童腹泻病例轮状病毒流行特征分析[J]. 疾病监测, 2016, 31(6): 463-470. DOI: 10.3784/j.issn.1003-9961.2016.06.006
引用本文: 耿启彬, 赖圣杰, 余建兴, 张子科, 杨婉琪, 李中杰, 吴建国, 杨维中. 中国26省(直辖市、自治区)2011-2014年5岁以下儿童腹泻病例轮状病毒流行特征分析[J]. 疾病监测, 2016, 31(6): 463-470. DOI: 10.3784/j.issn.1003-9961.2016.06.006
GENG Qi-bin, LAI Sheng-jie, YU Jian-xing, ZHANG Zi-ke, YANG Wan-qi, LI Zhong-jie, WU Jian-guo, YANG Wei-zhong. Epidemiological characteristics of rotavirus caused diarrhea in children aged 5 years in 26 provinces in China, 2011-2014[J]. Disease Surveillance, 2016, 31(6): 463-470. DOI: 10.3784/j.issn.1003-9961.2016.06.006
Citation: GENG Qi-bin, LAI Sheng-jie, YU Jian-xing, ZHANG Zi-ke, YANG Wan-qi, LI Zhong-jie, WU Jian-guo, YANG Wei-zhong. Epidemiological characteristics of rotavirus caused diarrhea in children aged 5 years in 26 provinces in China, 2011-2014[J]. Disease Surveillance, 2016, 31(6): 463-470. DOI: 10.3784/j.issn.1003-9961.2016.06.006

中国26省(直辖市、自治区)2011-2014年5岁以下儿童腹泻病例轮状病毒流行特征分析

Epidemiological characteristics of rotavirus caused diarrhea in children aged 5 years in 26 provinces in China, 2011-2014

  • 摘要: 目的 了解我国5岁以下儿童腹泻患者中轮状病毒的流行特征。方法 在国内26省(直辖市、自治区)162家医院的门/急诊中开展腹泻监测,收集腹泻病例临床和流行病学资料,同时采集病例粪便标本,送92家网络实验室采用酶联免疫吸附试验(ELISA)、反转录-聚合酶链反应(RT-PCR)和巢式PCR等方法检测轮状病毒,并分析2011-2014年不同时间、不同地区5岁以下儿童腹泻患者中轮状病毒检出率以及不同基因型的变异变迁情况。结果 在19849例儿童腹泻病例中,22.9%的病例检出轮状病毒,其中,1~2岁和6月龄至1岁儿童检出率最高,分别为29.0%和26.1%。轮状病毒在水样便中检出率最高,为26.2%。轮状病毒在冬季检出率最高,为39.4%,夏季检出率最低,为9.9%。轮状病毒在我国南部和中部地区的检出率最高,分别为28.0%和27.0%。A组轮状病毒为常见的血清型,占95.1%,其中G9 P8、G1 P8和G3 P8最为常见,分别占39.5%、16.8%和9.9%。2011年以来,G9 P8逐渐取代G1 P8和G3 P8成为目前我国最主要的流行株。结论 轮状病毒是我国5岁以下儿童腹泻的常见病原体,并且呈现明显的时间和空间流行特征,G9 P8为主要流行株。

     

    Abstract: Objective To investigate the epidemiological characteristics of rotavirus caused diarrhea in children aged 5 years in China. Methods Diarrhea surveillance was conducted in emergency or outpatient departments of 162 hospitals in 26 provinces of China, the clinical and epidemiological data of the diarrhea cases collected and fecal specimens collected from the cases were sent to 92 network laboratories for detection of rotavirus by enzyme linked immunosorbent assay (ELISA), reverse transcription PCR (RT-PCR) and nested PCR, etc. The detection rate of rotavirus in different areas, population and times as well as its gene mutation during 2011-2014 were analyzed. Results Among 19849 diarrheal cases surveyed, 22.9% were infected with rotavirus. The positive rate in age group 12-24 months was highest (29.0%), followed by age group 6-12 months (26.1%). The detection rate was highest in watery stool samples (26.2%). The detection rate of rotavirus was highest in winter (39.4%) and lowest in summer (9.9%) in a year. The detection rate was higher in southern China (28.0%) and central China (27.0%) than in other areas. The most prevalent genogroup of rotavirus detected was group A, accounting for 95.1%.Among rotavirus group A, G9 P8(39.5%), G1 P8(16.8%) and G3 P8(9.9%) were the most common genotype, and G9 P8 had become the most common type of rotavirus group A gradually in China instead of G1 P8 and G3 P8. Conclusion Rotavirus was the major pathogen causing diarrhea in children aged5 years in China. The positive detection of rotavirus showed obvious spatial-temporal pattern. G9 P8 was the most common genotypes of rotavirus group A.

     

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