夏岚, 张佩如, 饶正远, 肖月, 高文凤, 李仁忠, 吴建林. 四川省6158例涂阳肺结核患者耐药检测结果分析[J]. 疾病监测, 2016, 31(8): 692-696. DOI: 10.3784/j.issn.1003-9961.2016.08.017
引用本文: 夏岚, 张佩如, 饶正远, 肖月, 高文凤, 李仁忠, 吴建林. 四川省6158例涂阳肺结核患者耐药检测结果分析[J]. 疾病监测, 2016, 31(8): 692-696. DOI: 10.3784/j.issn.1003-9961.2016.08.017
XIA Lan, ZHANG Pei-ru, RAO Zheng-yuan, Xiao Yue, Gao Wen-feng, LI Ren-zhong, WU Jian-lin. Drug resistance of 6158 smear positive tuberculosis patients in Sichuan[J]. Disease Surveillance, 2016, 31(8): 692-696. DOI: 10.3784/j.issn.1003-9961.2016.08.017
Citation: XIA Lan, ZHANG Pei-ru, RAO Zheng-yuan, Xiao Yue, Gao Wen-feng, LI Ren-zhong, WU Jian-lin. Drug resistance of 6158 smear positive tuberculosis patients in Sichuan[J]. Disease Surveillance, 2016, 31(8): 692-696. DOI: 10.3784/j.issn.1003-9961.2016.08.017

四川省6158例涂阳肺结核患者耐药检测结果分析

Drug resistance of 6158 smear positive tuberculosis patients in Sichuan

  • 摘要: 目的 通过对2011-2015年期间四川省肺结核患者结核菌耐药特征分析,进一步掌握该省耐药结核病流行特点,为制定十三五防治规划提供参考依据。方法 回顾性调查2011年1月至2015年12月四川省12个市(州)108个县(市、区)中所有痰涂片阳性的肺结核患者及耐多药结核病高危人群痰标本分离结核分枝杆菌对异烟肼(INH)、利福平(RFP)、氧氟沙星(OFX)和卡那霉素(KM)的药物敏感性,对其耐药情况和流行特征进行对比分析。结果 筛查的6158例患者中,总耐药率为43.10%,初治患者耐药率为32.00%,复治患者耐药率为53.97%,差异有统计学意义(2=303,P0.01),任何耐药顺位为INH OFX RFP KM。耐多药结核病患者占耐药患者比例为30.97%,广泛耐药结核病患者占耐多药结核病患者的18.13%。男性患者耐药率为45.19%,高于女性(2=21.06,P0.01);农村患者耐药率为45.77%,高于城市;30~60岁年龄组患者耐药率高于其他年龄组。结论 四川省痰涂片阳性的肺结核患者及耐多药结核病高危人群耐药率高于全国水平,且高于2010年该省第五次流行病学调查水平。45~60岁农村男性患者是耐药防控的重点人群。

     

    Abstract: Objective To analyze the drug resistance in patients with pulmonary tuberculosis (TB) and understand the epidemiological characteristics of drug resistant tuberculosis in Sichuan province during 2011-2015. Methods Retrospective survey was conducted among all sputum smear positive pulmonary TB patients in 108 counties (districts) of 12 prefectures (municipality) and MDR-TB high-risk population by detecting their drug susceptibility to isoniazid, rifampicin, ofloxacin and kanamycin,comparative analyses of their drug resistance and epidemiological characteristics were conducted. Results A total of 6158 TB patients were surveyed, the overall drug resistance rate was 43.10%, the drug resistance rate was 32.00% in new TB patients and 53.97% in re-treated patients, there was significant difference (2=303, P0.01). The resistant rate to isoniazid was highest, followed by ofloxacin, rifampicin and kanamycin.MDR-TB patients accounted for 30.97% of drug resistant TB patients, XDR-TB patients accounted for 18.13% of MDR-TB patients. The drug resistant rate was 45.19% in males, higher than that in females (2=21.06, P0.01). The drug resistant rate was 45.77% in rural patients, higher than that in urban patients. The drug resistan rate in patients aged 30-60 was higher than that in other age groups. Conclusion The drug resistant rate of sputum smear positive TB patients and MDR-TB patients in Sichuan washigher than national level, and higher than that in the fifth epidemiological investigation in Sichuan during 2010. Male patients aged 45-60 years in rural areas were the key population in the prevention and control of drug resistance TB in Sichuan.

     

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