Abstract: Objective To understand the infection status of Brucella in human in Sichuan province in 2014, and provide evidence for the prevention and control of brucellosis. Methods Epidemiological survey was conducted among the suspected brucellosis cases detected in the outpatient department of Sichuan CDC in 2014 and serum antibody detection was conducted with tube agglutination test. Results A total of 305 suspected brucellosis cases were detected, 32 cases were serum antibody positive for Brucella (10.49%). The sex specific difference was significant. The brucellosis patients were mainly distributed in age group 40-60 years in 8 prefectures, accounting for 78.13%, and the serologicpositive cases in Meishan accounted for the highest proportion (25.00%). The case number in people engaged in goat or cattle raising was highest. The main clinical manifestations were fever (90.63%), hyperhidrosis (62.50%), fatigue (68.75%) and joint pain (59.38%). The main infection sources were goat, cattle and its products. The transmission routes were the contact with goat and cattle or eating mutton or beef. Conclusion Human brucellosis was detected in many areas in Sichuan in 2014. Underreport of brucellosis cases was serious and the reemerging of brucellosis epidemic was obvious. It is necessary to strengthen the prevention and control of brucellosis in Sichuan.