Abstract: Objective To understand the epidemiological and serological characteristics of brucellosis in Jiangmen,Guangdong province,and provide scientific evidence for the prevention and control of brucellosis. Methods The descriptive epidemiological analysis was conducted by using the incidence data and surveillance results of human brucellosis in Jiangmen. Results From 2007 to 2015,a total of 121 brucellosis cases were reported with an average annual incidence of 0.30/100 000,and no death case was reported. A significant increasing trend in brucellosis incidence during the period was observed (2=136.94,P0.001). The top 3 districts in reporting brucellosis cases were Xinhui (46 cases),Pengjiang (21 cases) and Heshan (18 cases),the cases reported in the 3 districts accounted for 70.25% of the total. Of all the reported cases,66.12% were males and 33.89% were females,respectively; 32.23% were owners of cattle and sheep and 50.41% were aged 40-59 years. In the 115 reported cases from 2011 to 2015,the median interval between onset and diagnosis was 39 days. Totally 825 blood samples were collected from the owners of cattle and sheep from 2012 to 2015 and 6 were positive for Brucella antibody (0.73%). Conclusion The increasing trend of brucellosis incidence was obvious in Jiangmen. Further surveillance and comprehensive prevention and treatment should be conducted to control human brucellosis in Jiangmen.