Abstract: Objective To describe the design and management mechanism of standard coding system of disease prevention and control information system in China, analyze the application status and effect of standard coding system, and discuss the problems existing in the information coding of disease prevention and control. Methods The data collected through standard encoding system were used to analyze the relationship between these data and the subsystems of China Disease Prevention and Control Information System and its application effect, the problems existed in standard coding system were studied through consulting relevant literature. Results The standard coding system is responsible for the creation and management of the basic information coding and business information coding of all the business subsystems on the platform of the Chinese disease prevention and control information system. It is the bridge and link for information sharing and interaction of each subsystem. However, because the development of business needs is not synchronized with the standard construction and improvement, the standard coding system cannot meet the needs of the interaction between the platform business subsystem and the external system. Conclusion In the context of Internet +, the health information sharing across region, across agency and across-industry has become more important, so roading, bridging or opening new route between systems to achieve the interconnection between systems is particularly important.