Abstract: Objective To understand the epidemiological characteristics of hand, foot and mouth disease(HFMD) in Yiwu,Zhejiang province,and provide evidence for the local prevention and control of HFMD. Methods The incidence data of HFMD in Yiwu during 2008 -2016 were collected from National Notifiable Infectious Disease Reporting System. The database was established with Excel and the epidemiological and etiological analysis were conducted respectively. Results A total of 32 554 hand foot and mouth cases,including 12 deaths(0.04%),were reported during this period. Among the reported cases,20 613 occurred in males and 11 941 occurred in females. The gender distribution of the cases differed with year(2=41.939, P=0.001). Among the reported cases,10 were Enterovirus 71(EV71)infections,2 were other enterovirus infections. The cases were reported all the year round,but the cases reported during April-July accounted for high proportion (60.64%)(19 742/32 554). The monthly distribution of the cases varied with year(2=9 159.738, P=0.001). Most cases (65.33%)(21 267/32 554)were reported in Choucheng,Jiangdong,Beiyuan,and Choujiang communities. About 95.76% of cases occurred in children aged 5 years. Conclusion Most HFMD cases occurred in children aged 5 years and cases were reported in every month. More cases might occur in 2017,it is necessary to take targeted prevention and control measures.