Abstract: Objective To analyze the epidemiological characteristics of severe fever with thrombocytopenia syndrome (SFTS)in Anqing,Anhui province,and provide scientific evidence for the prevention and control of the disease. Methods Descriptive epidemiological analysis was conducted by using the surveillance and epidemiological survey data of SFTS in Anqing during 2011-2016. Results A total of 316 SFTS cases were reported in Anqing during this period,the average annual incidence was 1.02/100 000,its incidence was in increase(P<0.001). Eleven cases were fatal,the case fatality rate was 3.48%,showing a decrease trend(P=0.005). The cases were mainly distributed in Tongcheng,Qianshan and Yuexi (66.77%)in the north of Anqing. The annual incidence began to increase in April and the peak season was during MayOctober. The differences in incidence and case fatality rate were not significant between males and females (χ²=0.225, P=0.635;χ²=0.154,P=0.695). The cases mainly occurred in age group 45-75 years(84.81%),all the death cases were aged >50 years. Most cases were farmers(83.86%). Up to 88.32% of the cases lived in mountain or hill area. The cases with field work history and with tick bite history within 2 weeks accounted for 64.96% and 13.14% respectively. The positive rate in case sample detection was 38.57%. Conclusion The incidence of STFS was in increase in Anqing,and its temporal and spatial distribution expanded. Middle aged and elderly farmers were mainly affected. Natural foci were mainly distributed in Tongcheng,Qianshan and Yuexi. It is necessary to strengthen prevention and control of SFTS and health education in the elderly in these areas.