张颖华, 陈秀华, 刘芸, 童锐, 王小光. 2014-2017年上海市闵行区副溶血弧菌的耐药性分析及预测[J]. 疾病监测, 2018, 33(5): 376-380. DOI: 10.3784/j.issn.1003-9961.2018.05.007
引用本文: 张颖华, 陈秀华, 刘芸, 童锐, 王小光. 2014-2017年上海市闵行区副溶血弧菌的耐药性分析及预测[J]. 疾病监测, 2018, 33(5): 376-380. DOI: 10.3784/j.issn.1003-9961.2018.05.007
Zhang Yinghua, Chen Xiuhua, Liu Yun, Tong Rui, Wang Xiaoguang. Analysis and prediction of antibiotic resistance of Vibrio parahaemolyticus isolates in Minhang district of Shanghai, 2014-2017[J]. Disease Surveillance, 2018, 33(5): 376-380. DOI: 10.3784/j.issn.1003-9961.2018.05.007
Citation: Zhang Yinghua, Chen Xiuhua, Liu Yun, Tong Rui, Wang Xiaoguang. Analysis and prediction of antibiotic resistance of Vibrio parahaemolyticus isolates in Minhang district of Shanghai, 2014-2017[J]. Disease Surveillance, 2018, 33(5): 376-380. DOI: 10.3784/j.issn.1003-9961.2018.05.007

2014-2017年上海市闵行区副溶血弧菌的耐药性分析及预测

Analysis and prediction of antibiotic resistance of Vibrio parahaemolyticus isolates in Minhang district of Shanghai, 2014-2017

  • 摘要: 目的 探讨副溶血弧菌对11种抗生素的耐药谱,敏感株的敏感性变化趋势并进行耐药预测。方法 收集2014-2017年上海市闵行区腹泻病监测点分离的副溶血弧菌,用K-B法测定其对头孢噻肟(CTX)、头孢呋辛(CXM)、头孢西丁(FOX)、环丙沙星(CIP)、诺氟沙星(NOR)、左氧氟沙星(LEV)、四环素(TE)、庆大霉素(CN)、萘啶酸(NA)、氯霉素(C)、复方新诺明(SXT)的敏感性。用单因素方差分析比较不同年份的抑菌圈直径差异,并分析其耐药趋势。结果 副溶血弧菌对CTX、CXM、FOX的耐药率分别为1.89%、19.40%和1.60%,中度耐药率分别为8.94%、39.24%和11.55%,对其他8种抗生素的敏感率均>94.00%。CTX、NA的敏感株抑菌圈直径有明显逐年减小趋势。预测副溶血弧菌可能分别在2021、2023年对CTX、NA中度耐药;2024、2027年耐药。结论 副溶血弧菌敏感株对抗生素的敏感性有逐年降低趋势,预计未来可能3~10年内敏感株逐渐耐药。

     

    Abstract: Objective To understand the spectrum and tendency of antibiotic resistance of Vibrio parahaemolyticus. Methods A total of 1 376 strains of V. parahaemolyticus were isolated from acute diarrheal patients in Minhang district of Shanghai from January 2014 to December 2017. K-B method was conducted for testing the susceptibility of the strains to 11 antibiotics,i.e. cefotaxime,cefuroxime,cefxitin,ciprofloxacin,norfloxacin,levofloxacin,tetracycline,gentamicin,nalidixic acid,chloramphenicol and sulfamethoxazole. Analysis of variance was used to compare the inhibition zone diameters of the antibiotics in different years,and the mean values of inhibition zone diameters were used for analysis of the resistance trend. Results The resistant rates of the strains to cefotaxime,cefuroxime and cefxitin were 1.89%,19.40% and 1.60% respectively, the intermediate resistant rates were 8.94%,39.24% and 11.55% respectively. The resistant rates to other 8 antibiotics were all > 94.00%. For the sensitive strains,the inhibition zone diameters of cefotaxime and nalidixic acid obviously decreased with year. It is predicted that V. parahaemolyticus would be intermediate resistant in 2021 and resistant in 2024 to cefotaxime,and intermediate resistant in 2023 and resistant in 2027 to nalidixic acid. Conclusion The sensitivity of V. parahaemolyticus to antibiotics showed a decline tendency over the past four years,and the antibiotic resistance is predicted to develop in sensitive strains in next 3-10 years.

     

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