Abstract:
Objective To understand the spectrum and tendency of antibiotic resistance of
Vibrio parahaemolyticus.
Methods A total of 1 376 strains of
V. parahaemolyticus were isolated from acute diarrheal patients in Minhang district of Shanghai from January 2014 to December 2017. K-B method was conducted for testing the susceptibility of the strains to 11 antibiotics,i.e. cefotaxime,cefuroxime,cefxitin,ciprofloxacin,norfloxacin,levofloxacin,tetracycline,gentamicin,nalidixic acid,chloramphenicol and sulfamethoxazole. Analysis of variance was used to compare the inhibition zone diameters of the antibiotics in different years,and the mean values of inhibition zone diameters were used for analysis of the resistance trend.
Results The resistant rates of the strains to cefotaxime,cefuroxime and cefxitin were 1.89%,19.40% and 1.60% respectively, the intermediate resistant rates were 8.94%,39.24% and 11.55% respectively. The resistant rates to other 8 antibiotics were all > 94.00%. For the sensitive strains,the inhibition zone diameters of cefotaxime and nalidixic acid obviously decreased with year. It is predicted that
V. parahaemolyticus would be intermediate resistant in 2021 and resistant in 2024 to cefotaxime,and intermediate resistant in 2023 and resistant in 2027 to nalidixic acid.
Conclusion The sensitivity of
V. parahaemolyticus to antibiotics showed a decline tendency over the past four years,and the antibiotic resistance is predicted to develop in sensitive strains in next 3-10 years.