Abstract: Objective To understand the molecular type and circulation of food bone Salmonella typhimurium in Neijiang of Sichuan province,and provide evidence for the prevention and control of S. typhimurium infection. Methods The data of foodborne disease cases were collected from 4 sentinel hospitals in Neijiang. The stool samples were collected from the patients to isolate S. typhimurium. The molecular typing of the isolates was performed by using pulsed field gel electrophoresis(PFGE) and the electrophoresis pattern was analyzed with software Bionumerics 6.6. Results A total of 48 strains of S. typhimurium were isolated in 2017,mainly from children. Among the isolates,89.6%(43/48) were detected between May and October and the detection number was highest in July. Genotyping results showed that 48 strains of S. typhimurium can be divided into 39 molecular patterns. The strain number in each pattern ranged from 1 to 5,and the strains in each pattern shared 65%-100% similarity. There were five groups of strains sharing 100% similarity,but related cases had no contact history except one case group had common preserved egg exposure history. Conclusion S. typhimurium was mainly detected in children in Neijiang, and most infections occurred in summer and autumn. The preserved egg might be the source of infection. The molecular typing results suggest that association among the strains was not strong,but some strains still have the potential to cause outbreak. It is necessary to strengthen the surveillance for S. typhimurium.