Abstract: On September 9, 2017, a businessman from Bangladesh was confirmed to be infected with Chikungunya fever virus by the Baiyun airport port inspection department of Guangzhou Entry-Exit Inspection and Quarantine Bureau. On the same day, the businessman arrived in Wenzhou and checked in a local hotel. It was the first confirmed Chikungunya fever case in Wenzhou. A series of prevention and control measures were taken timely by Wenzhou center for disease control and prevention to prevent the secondary ceases. It is necessary to strengthen disease surveillance capability and improve public health emergency response to prevent the possible outbreak of diseases.